LOCALLY-ADVANCED PROSTATE CANCER IN THE ELDERLY: SHOULD WE REVISIT OUR TREATMENT PARADIGMS?


DNA Gyrase as a Target for Quinolones

Bacterial DNA gyrase is a type II topoisomerase that can introduce negative supercoils to DNA substrates and is a clinically-relevant target for the development of new antibacterials.DNA gyrase is one of the primary targets of quinolones, broad-spectrum antibacterial agents and are used as a first-line drug for various types of infections.However,

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